Perception-motivated parallel algorithms for haptics

Negli ultimi anni l\u2019utilizzo di dispositivi aptici, atti cio\ue8 a riprodurre l\u2019interazione fisica con l\u2019ambiente remoto o virtuale, si sta diffondendo in vari ambiti della robotica e dell\u2019informatica, dai videogiochi alla chirurgia robotizzata eseguita in teleoperazione, dai cellulari alla riabilitazione. In questo lavoro di tesi abbiamo voluto considerare nuovi punti di vista sull\u2019argomento, allo scopo di comprendere meglio come riportare l\u2019essere umano, che \ue8 l\u2019unico fruitore del ritorno di forza, tattile e di telepresenza, al centro della ricerca sui dispositivi aptici. Allo scopo ci siamo focalizzati su due aspetti: una manipolazione del segnale di forza mutuata dalla percezione umana e l\u2019utilizzo di architetture multicore per l\u2019implementazione di algoritmi aptici e robotici. Con l\u2019aiuto di un setup sperimentale creato ad hoc e attraverso l\u2019utilizzo di un joystick con ritorno di forza a 6 gradi di libert\ue0, abbiamo progettato degli esperimenti psicofisici atti all\u2019identificazione di soglie differenziali di forze/coppie nel sistema mano-braccio. Sulla base dei risultati ottenuti abbiamo determinato una serie di funzioni di scalatura del segnale di forza, una per ogni grado di libert\ue0, che permettono di aumentare l\u2019abilit\ue0 umana nel discriminare stimoli differenti. L\u2019utilizzo di tali funzioni, ad esempio in teleoperazione, richiede la possibilit\ue0 di variare il segnale di feedback e il controllo del dispositivo sia in relazione al lavoro da svolgere, sia alle peculiari capacit\ue0 dell\u2019utilizzatore. La gestione del dispositivo deve quindi essere in grado di soddisfare due obbiettivi tendenzialmente in contrasto, e cio\ue8 il raggiungimento di alte prestazioni in termini di velocit\ue0, stabilit\ue0 e precisione, abbinato alla flessibilit\ue0 tipica del software. Una soluzione consiste nell\u2019affidare il controllo del dispositivo ai nuovi sistemi multicore che si stanno sempre pi\uf9 prepotentemente affacciando sul panorama informatico. Per far ci\uf2 una serie di algoritmi consolidati deve essere portata su sistemi paralleli. In questo lavoro abbiamo dimostrato che \ue8 possibile convertire facilmente vecchi algoritmi gi\ue0 implementati in hardware, e quindi intrinsecamente paralleli. Un punto da definire rimane per\uf2 quanto costa portare degli algoritmi solitamente descritti in VLSI e schemi in un linguaggio di programmazione ad alto livello. Focalizzando la nostra attenzione su un problema specifico, la pseudoinversione di matrici che \ue8 presente in molti algoritmi di dinamica e cinematica, abbiamo mostrato che un\u2019attenta progettazione e decomposizione del problema permette una mappatura diretta sulle unit\ue0 di calcolo disponibili. In aggiunta, l\u2019uso di parallelismo a livello di dati su macchine SIMD permette di ottenere buone prestazioni utilizzando semplici operazioni vettoriali come addizioni e shift. Dato che di solito tali istruzioni fanno parte delle implementazioni hardware la migrazione del codice risulta agevole. Abbiamo testato il nostro approccio su una Sony PlayStation 3 equipaggiata con un processore IBM Cell Broadband Engine.In the last years the use of haptic feedback has been used in several applications, from mobile phones to rehabilitation, from video games to robotic aided surgery. The haptic devices, that are the interfaces that create the stimulation and reproduce the physical interaction with virtual or remote environments, have been studied, analyzed and developed in many ways. Every innovation in the mechanics, electronics and technical design of the device it is valuable, however it is important to maintain the focus of the haptic interaction on the human being, who is the only user of force feedback. In this thesis we worked on two main topics that are relevant to this aim: a perception based force signal manipulation and the use of modern multicore architectures for the implementation of the haptic controller. With the help of a specific experimental setup and using a 6 dof haptic device we designed a psychophysical experiment aimed at identifying of the force/torque differential thresholds applied to the hand-arm system. On the basis of the results obtained we determined a set of task dependent scaling functions, one for each degree of freedom of the three-dimensional space, that can be used to enhance the human abilities in discriminating different stimuli. The perception based manipulation of the force feedback requires a fast, stable and configurable controller of the haptic interface. Thus a solution is to use new available multicore architectures for the implementation of the controller, but many consolidated algorithms have to be ported to these parallel systems. Focusing on specific problem, i.e. the matrix pseudoinversion, that is part of the robotics dynamic and kinematic computation, we showed that it is possible to migrate code that was already implemented in hardware, and in particular old algorithms that were inherently parallel and thus not competitive on sequential processors. The main question that still lies open is how much effort is required in order to write these algorithms, usually described in VLSI or schematics, in a modern programming language. We show that a careful task decomposition and design permit a mapping of the code on the available cores. In addition, the use of data parallelism on SIMD machines can give good performance when simple vector instructions such as add and shift operations are used. Since these instructions are present also in hardware implementations the migration can be easily performed. We tested our approach on a Sony PlayStation 3 game console equipped with IBM Cell Broadband Engine processor

Pose Measurement of Flexible Medical Instruments Using Fiber Bragg Gratings in Multi-Core Fiber

Accurate navigation of flexible medical instruments like catheters require the knowledge of its pose, that is its position and orientation. In this paper multi-core fibers inscribed with fiber Bragg gratings (FBG) are utilized as sensors to measure the pose of a multi-segment catheter. A reconstruction technique that provides the pose of such a fiber is presented. First, the measurement from the Bragg gratings are converted to strain then the curvature is deduced based on those strain calculations. Next, the curvature and the Bishop frame equations are used to reconstruct the fiber. This technique is validated through experiments where the mean error in position and orientation is observed to be less than 4.69 mm and 6.48 degrees, respectively. The main contributions of the paper are the use of Bishop frames in the reconstruction and the experimental validation of the acquired pose

Position-based Dynamics Simulator of Brain Deformations for Path Planning and Intra-Operative Control in Keyhole Neurosurgery

Many tasks in robot-assisted surgery require planning and controlling manipulators' motions that interact with highly deformable objects. This study proposes a realistic, time-bounded simulator based on Position-based Dynamics (PBD) simulation that mocks brain deformations due to catheter insertion for pre-operative path planning and intra-operative guidance in keyhole surgical procedures. It maximizes the probability of success by accounting for uncertainty in deformation models, noisy sensing, and unpredictable actuation. The PBD deformation parameters were initialized on a parallelepiped-shaped simulated phantom to obtain a reasonable starting guess for the brain white matter. They were calibrated by comparing the obtained displacements with deformation data for catheter insertion in a composite hydrogel phantom. Knowing the gray matter brain structures' different behaviors, the parameters were fine-tuned to obtain a generalized human brain model. The brain structures' average displacement was compared with values in the literature. The simulator's numerical model uses a novel approach with respect to the literature, and it has proved to be a close match with real brain deformations through validation using recorded deformation data of in-vivo animal trials with a mean mismatch of 4.73$\pm$2.15%. The stability, accuracy, and real-time performance make this model suitable for creating a dynamic environment for KN path planning, pre-operative path planning, and intra-operative guidance.Comment: 8 pages, 8 figures. This article has been accepted for publication in a future issue of IEEE Robotics and Automation Letters, but has not been fully edited. Content may change prior to final publication. 2377-3766 (c) 2021 IEEE. Personal use is permitted, but republication/redistribution requires IEEE permission. A. Segato and C. Di Vece equally contribute

Automatic optimized 3D path planner for steerable catheters with heuristic search and uncertainty tolerance

In this paper, an automatic planner for minimally invasive neurosurgery is presented. The solution can provide the surgeon with the best path to connect a user-defined entry point with a target in accordance with specific optimality criteria guaranteeing the clearance from obstacles which can be found along the insertion pathway. The method is integrated onto the EDEN2020∗ programmable bevel-tip needle, a multi-segment steerable probe intended to be used to perform drug delivery for glioblastomas treatment. A sample-based heuristic search inspired to the BIT* algorithm is used to define the optimal solution in terms of path length, followed by a smoothing phase required to meet the kinematic constraint of the catheter. To account for inaccuracies in catheter modeling, which could de- termine unexpected control errors over the insertion procedure, an uncertainty margin is defined so that to include a further level of safety for the planning algorithm. The feasibility of the proposed solution was demonstrated by testing the method in simulated neurosurgical scenarios with different degree of obstacles occupancy and against other sample-based algorithms present in literature: RRT, RRT* and an enhanced version of the RRT-Connect

Proteomics identifies neddylation as a potential therapy target in small intestinal neuroendocrine tumors.

Patients with small intestinal neuroendocrine tumors (SI-NETs) frequently develop spread disease; however, the underlying molecular mechanisms of disease progression are not known and effective preventive treatment strategies are lacking. Here, protein expression profiling was performed by HiRIEF-LC-MS in 14 primary SI-NETs from patients with and without liver metastases detected at the time of surgery and initial treatment. Among differentially expressed proteins, overexpression of the ubiquitin-like protein NEDD8 was identified in samples from patients with liver metastasis. Further, NEDD8 correlation analysis indicated co-expression with RBX1, a key component in cullin-RING ubiquitin ligases (CRLs). In vitro inhibition of neddylation with the therapeutic agent pevonedistat (MLN4924) resulted in a dramatic decrease of proliferation in SI-NET cell lines. Subsequent mass spectrometry-based proteomics analysis of pevonedistat effects and effects of the proteasome inhibitor bortezomib revealed stabilization of multiple targets of CRLs including p27, an established tumor suppressor in SI-NET. Silencing of NEDD8 and RBX1 using siRNA resulted in a stabilization of p27, suggesting that the cellular levels of NEDD8 and RBX1 affect CRL activity. Inhibition of CRL activity, by either NEDD8/RBX1 silencing or pevonedistat treatment of cells resulted in induction of apoptosis that could be partially rescued by siRNA-based silencing of p27. Differential expression of both p27 and NEDD8 was confirmed in a second cohort of SI-NET using immunohistochemistry. Collectively, these findings suggest a role for CRLs and the ubiquitin proteasome system in suppression of p27 in SI-NET, and inhibition of neddylation as a putative therapeutic strategy in SI-NET

Adhesion to carbon nanotube conductive scaffolds forces action-potential appearance in immature rat spinal neurons

In the last decade, carbon nanotube growth substrates have been used to investigate neurons and neuronal networks formation in vitro when guided by artificial nano-scaled cues. Besides, nanotube-based interfaces are being developed, such as prosthesis for monitoring brain activity. We recently described how carbon nanotube substrates alter the electrophysiological and synaptic responses of hippocampal neurons in culture. This observation highlighted the exceptional ability of this material in interfering with nerve tissue growth. Here we test the hypothesis that carbon nanotube scaffolds promote the development of immature neurons isolated from the neonatal rat spinal cord, and maintained in vitro. To address this issue we performed electrophysiological studies associated to gene expression analysis. Our results indicate that spinal neurons plated on electro-conductive carbon nanotubes show a facilitated development. Spinal neurons anticipate the expression of functional markers of maturation, such as the generation of voltage dependent currents or action potentials. These changes are accompanied by a selective modulation of gene expression, involving neuronal and non-neuronal components. Our microarray experiments suggest that carbon nanotube platforms trigger reparative activities involving microglia, in the absence of reactive gliosis. Hence, future tissue scaffolds blended with conductive nanotubes may be exploited to promote cell differentiation and reparative pathways in neural regeneration strategies

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC

Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe

Elliptic flow of electrons from heavy-flavour hadron decays at mid-rapidity in Pb-Pb collisions at root s(NN)=2.76 TeV

The elliptic flow of electrons from heavy-flavour hadron decays at mid-rapidity (|y| <0.7) is measured in Pb-Pb collisions at TeV with ALICE at the LHC. The particle azimuthal distribution with respect to the reaction plane can be parametrized with a Fourier expansion, where the second coefficient (v (2)) represents the elliptic flow. The v (2) coefficient of inclusive electrons is measured in three centrality classes (0-10%, 10-20% and 20-40%) with the event plane and the scalar product methods in the transverse momentum (p (T)) intervals 0.5-13 GeV/c and 0.5-8 GeV/c, respectively. After subtracting the background, mainly from photon conversions and Dalitz decays of neutral mesons, a positive v (2) of electrons from heavy-flavour hadron decays is observed in all centrality classes, with a maximum significance of 5.9 sigma in the interval 2 <p (T) <2.5 GeV/c in semi-central collisions (20-40%). The value of v (2) decreases towards more central collisions at low and intermediate p (T) (0.5 <p (T) <3 GeV/c). The v (2) of electrons from heavy-flavour hadron decays at mid-rapidity is found to be similar to the one of muons from heavy-flavour hadron decays at forward rapidity (2.5 <y <4). The results are described within uncertainties by model calculations including substantial elastic interactions of heavy quarks with an expanding strongly-interacting medium.Peer reviewe

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries